Proteomics in Biomarker Discovery for Prostate Cancer
نویسندگان
چکیده
The use of prostate specific antigen (PSA)-based screening of prostate cancer (PCa) results with overdiagnosis of the disease, unnecessary biopsies and high medical cost treatments. The discovery of new biomarkers in blood, urine or tissue that will permit early detection and treatment of patients with aggressive disease and, concomitantly, avoid overtreatment for low risk cases are urgently needed. Proteomic technologies are providing the tools needed to discover and identify disease associated biomarkers. The application of these technologies to search for potential diagnostic/prognostic biomarkers associated with PCa has shown constant growth in the last 15 years. The main clinical focus in PCa research nowadays is the discovery of biomarker(s) for diagnosis and distinction between aggressive and indolent cancers, followed by prognostic and response to treatment biomarker(s). Different proteomic technologies and various biological samples have been analyzed with the aim of identifying diagnostic and prognostic biomarkers and developing a deeper understanding of the disease at the molecular level. Here we will overview the current status in PCa diagnosis nowadays, new emerging biomarkers for PCa, different proteomics technologies applied in the study of PCa and explored sources for biomarker discovery. Emphasis will be given on proteomics research that has been conducted in our lab in the last few years with brief overview of the major findings and putative clinical application.
منابع مشابه
Proteomics Applications in Health: Biomarker and Drug Discovery and Food Industry
Advancing in genome sequencing has greatly propelled the understanding of the living world, however, it is insufficient for full description of a biological system. Focusing on, proteomics has emerged as another large-scale platform for improving the understanding of biology. Proteomic experiments can be used for different aspects of clinical and health sciences such as food technology, biomark...
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Advancing in genome sequencing has greatly propelled the understanding of the living world, however, it is insufficient for full description of a biological system. Focusing on, proteomics has emerged as another large-scale platform for improving the understanding of biology. Proteomic experiments can be used for different aspects of clinical and health sciences such as food technology, biomark...
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Proteomics enables understanding the composition, structure, function and interactions of the entire protein complement of a cell, a tissue, or an organism under exactly defined conditions. Some factors such as stress or drug effects will change the protein pattern and cause the present or absence of a protein or gradual variation in abundances. Changes in the proteome provide a snapshot of the...
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